Hyperpigmentation Cream Mobile Web - Version 1.1 Hyperpigmentation is a common condition where areas of the skin color darkens due to increased melanin. This is usually a harmless condition caused by medications, sun exposure, illness, or aging. Post acne hyperpigmentation is another common reason. Acne can leave dark scars and marks on the skin. Many individuals feel self-conscious about the dark splotches and spots and want them to disappear, especially when they are on the face. There are several options for treating and lightening the skin.