Weight Loss Supplements Trials - Version 1.0 Weight loss supplements to help you lose weight. Losing weight can dramatically improve your emotional and physical health, but it can be a slow process. So it's no wonder that 15% of American adults use diet supplements to boost weight loss, opting for a range of products that claim to decrease appetite, block fat absorption, or increase metabolism.Currently, most weight loss experts do not recommend many products marketed as weight loss supplements because of a lack of evidence. Also certain diet supplements, including ephedra, may cause heart attack and stroke. (Ephedra, also known as ma huang, was banned by the FDA in 2004 for sale in the U.S.)However, there are some proven weight loss supplements available. Which weight loss supplements may be safe and helpful during a diet? Here's a rundown on six products you can buy at most health food or drugstores that have some weight loss evidence behind them