Exe Vaccine Professional - Version 4.0 EXE Vaccine protects your PC by acting as an executable file filter. It attaches to the operating system and filters all executable files, be it .exe .com .dll .drv .sys .dpl etc from all drives and all network shares against a list of files or paths, you, the administrator provide as trusted applications. If a prohibited executable (one not in the allow list or one explicitly defined in the deny list) is loaded, a customizable popup box shows up